
In 1985, Alfred E. Mann set out to solve one of the biggest challenges in med tech: the gap between a promising idea and a product that actually reaches patients. He called it the valley of death. The organization he founded — formerly the Alfred E. Mann Foundation, now huMannity Medtec — has spent over four decades building the engineering, regulatory, and clinical expertise to close that gap, producing more than 600 patents and spinouts that include Axonics, MiniMed, and Advanced Bionics along the way. For an organization built around scientists, engineers, regulatory specialists, and business developers, alignment doesn’t happen by accident. It has to be engineered, the same way we’d engineer anything else we care about.
John Rivera, Head of Research and Development at huMannity Medtec, has spent his career at the forefront of this field. Through years of research and product development, he’s identified four guiding principles that shape his approach to neuromodulation technology. These insights—rooted in a deep understanding of neurophysiology, engineering, and patient needs—highlight the complexities of creating effective, future-ready implantable devices.
Staying at the forefront of innovation is not just a goal but a necessity for medtech companies looking to make a difference. It’s a mindset that requires everyone’s participation
To say that recruiting extremely talented people at the forefront of medical technology is critical to our success is quite the understatement.
There are Med Tech companies only interested in swinging for the fences, settling for nothing less than radical, groundbreaking innovations. There are other organizations that live on the periphery, finding value in refining existing technologies. But why can’t you do both?
Nearly forty years ago, our organization—then known as The Alfred E. Mann Foundation for Scientific Research, or AMF—was founded with a clear public mission: to research and develop innovative medical technologies in search of solutions that address unmet and undermet medical conditions.